Concentrated oat beta-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial
Katie M Queenan , Maria L Stewart , Kristen N Smith , William Thomas , R Gary Fulcher and Joanne L Slavin

Background

Soluble fibers lower serum lipids, but are difficult to incorporate into products acceptable to consumers. We investigated the physiological effects of a concentrated oat beta-glucan on cardiovascular disease (CVD) endpoints in human subjects. We also compared the fermentability of concentrated oat beta-glucan with inulin and guar gum in a model intestinal fermentation system.

Methods

Seventy-five healthy hypercholesterolemic men and women were randomly assigned to one of two treatments: 6 grams/day concentrated oat beta-glucan or 6 grams/day dextrose (control). Fasting blood samples were collected at baseline, week 3, and week 6 and analyzed for total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, glucose, insulin, homocysteine and C-reactive protein (CRP). To estimate colonic fermentability, 0.5g concentrated oat beta-glucan was incubated in a batch model intestinal fermentation system, using human fecal inoculum to provide representative microflora. Fecal donors were not involved with the beta-glucan feeding trial. Inulin and guar gum were also incubated in separate serum bottles for comparison.

Results

Oat beta-glucan produced significant reduction from baseline in total cholesterol (-0.3+/-0.1 mmol/L) and LDL cholesterol (-0.3+/-0.1 mmol/L), and the reduction in LDL cholesterol was significantly greater than in the control group (p=0.03). Concentrated oat beta-glucan was a fermentable fiber and produced total SCFA and acetate concentrations similar to inulin and guar gum. Concentrated oat beta-glucan produced the highest concentrations of butyrate at 4, 8, and 12 hours.

Conclusion

Six grams concentrated oat beta-glucan per day for six weeks significantly reduced total and LDL cholesterol in subjects with elevated cholesterol, and the LDL cholesterol reduction was greater than the change in the control group. Based on a model intestinal fermentation, this oat beta-glucan was fermentable, producing higher amounts of butyrate than other fibers. Thus, a practical dose of oat beta-glucan can significantly lower serum lipids in a high-risk population and may improve colon health.

 

Dietary fiber related links:

Total dietary fiber, soluble fiber, insoluble fiber content of foods
Definitions of dietary fiber food.
List of high fiber food: vegetables and fruits
List of low fiber foods
Dietary fiber: Daily Reference Intakes (DRIs) for fiber



© 2007 Queenan et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

This is a provisional abstract. The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.

Nutrition Journal 2007, 6:6     doi:10.1186/1475-2891-6-6


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